Introduction: Mandibular continuity defects after pathologic resections or traumatic events are difficult cases for reconstruction. Defects involving both hard and soft tissue Loss are more challenging, because of problems in soft tissue coverage. The role of the submental Flap in this regard is presented. Materials and Methods: In a retrospective study from the archived files of Ghaem Hospital, Mashhad, Iran between 2007– 2016, lateral mandibular defects that were managed with submental Flap for soft tissue coverage were selected. Results: Ten patients had been treated, of whom four cases were due to trauma/gunshot events and six cases were defined as pathologic resection; five patients with malignant lesions and one with benign intraosseous pathology, but with soft tissue invasion. There was one complication overall, concerning orocutaneous fistula formation. Conclusion: Submental Flap is indicated for coverage of the reconstruction plate when the lateral mandible is resected/avulsed with soft tissue Loss limited to the oral cavity or due to through and through defects in the lower third of the face.